A multicompartment hard capsule with control release properties

Details A multicompartment hard capsule with control release properties A multicompartment hard capsule with control release properties

A - Human Necessities

61

K

A61K 9/52 (2006.01)

Patent

CA 2201924

The present invention relates to a hard capsule (10) made from a material such as gelatin, starch or a hydrophilic polymer. The capsule of the present invention is formulated into a delivery system which incorporates pharmacologically active components in three or more distinct compartments. When three compartments are utilized in the capsule, the outer compartment (12) incorporates a drug and excipients into a layer which coats the outer part of the capsule. This layer represents the rapid release portion of the delivery system. The intermediate compartment (11) comprises a powder formulation comprised of a drug and excipients which represents the intermediary speed release portion of the delivery system. The innermost compartment incorporates the active ingredient or ingredients in a multiparticulate form, such as small pellets (14) and represents the slow release component of the delivery system.

L'invention concerne une gélule (10) réalisée en un produit tel que la gélatine, l'amidon ou un polymère hydrophile. Cette gélule constitue un système d'administration où la composante active du point de vue pharmacologique est placée dans trois compartiments séparés ou davantage. Lorsque la gélule comprend trois compartiments, le compartiment externe (12) est constitué par une couche externe formant un revêtement sur la gélule et contenant un médicament et des excipients. Cette couche permet une libération rapide du médicament. Le compartiment intermédiaire (11) contient une poudre constituée d'un médicament et d'excipients, qui représente la partie du système assurant une libération à une vitesse intermédiaire. Le compartiment le plus interne contient le ou les ingrédients actifs sous une forme multiparticulaire, par exemple de petits granulés (14), et il représente la partie du système assurant une libération lente.

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