C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/12 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61K 39/44 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2478415
AbstractThe present invention relates to a multi-functional targeting complex for inducing a specific immuno-stimulatory reaction, preferably, phagocytosis, against at least one target pathogenic agent. The complex of the invention comprises at least one target recognition component comprising a molecule that specifically binds to the desired target agent, an immuno-active component comprising an immuno-stimulatory agent; and optionally, a connecting component that associates the targeting component and the immuno-active component. The complex of the invention provides an effective therapeutic prevention and treatment of various pathogenic disorders, such as mastitis in caws and furunculosis in fish. The invention further relates to compositions comprising the targeting complex, methods of treatment and uses thereof.
La présente invention concerne un complexe de ciblage multifonctionnel permettant d'induire une réaction immuno-stimulante spécifique, de préférence, la phagocytose, contre au moins un agent pathogène cible. Le complexe décrit dans cette invention comprend au moins un composant de reconnaissance cible contenant une molécule qui se lie spécifiquement à l'agent cible souhaité, un composant immuno-actif contenant un agent immuno-stimulant; et, éventuellement, un composant de liaison associant le composant de ciblage et le composant immuno-actif. Le complexe décrit dans l'invention et particulièrement efficace pour la prophylaxie et le traitement de divers troubles pathogènes, tels que la mastite chez les vaches et la furonculose chez les poissons. La présente invention concerne également des compositions comprenant ce complexe de ciblage, des méthodes thérapeutiques ainsi que des procédés d'utilisation de ce complexe.
Morag Ely
Pinchasov Yosef
Pitcovski Jacob
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Yamit Biotechnologies Ltd.
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