A myeloid precursor cell useful for gene therapy and for...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/85 (2006.01) C12N 9/16 (2006.01) C12N 9/24 (2006.01) C12N 15/11 (2006.01) C12N 15/86 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2348736

A long-lived, myeloid-committed stem cell population is disclosed. Also disclosed are methods and compositions for targeting this population with retrovirus vectors in gene therapy protocols for correcting congenital disorders of myeloid system and for potentiating immune responses to defined tumor and viral antigens.

L'invention concerne une population de cellules souches spécifiques au myéloïdet présentant une durée de vie prolongée. Elle concerne également des procédés et des compositions servant à cibler cette population avec des vecteurs de rétrovirus dans des protocoles de thérapie génique servant à corriger des maladies congénitales du système myéloïde et à potentialiser des réponses immunes à des tumeurs définies et à des antigènes viraux.

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