A new calcium phosphate cement composition and a method for...

C - Chemistry – Metallurgy – 04 – B

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C04B 12/02 (2006.01) A61L 27/12 (2006.01) C04B 28/34 (2006.01)

Patent

CA 2438742

The invention describes a new calcium phosphate cement powder, whose composition can best be described over the Ca/P molar ratio range of 1.35 to 1.40, most preferably 1.39, and whose two components were prepared by wet chemical synthesis procedures. One component is chemically- synthesized, bi-phasic alpha-TCP (Ca3(PO4)2, 95 wt%) + HA (Ca10(PO4)6(OH)2, 5 wt%) powder, while the second component is again a chemically-synthesized, single-phase DCPD (CaHPO4~2H2O) powder. A setting solution (Na2HPO4~2H2O) is used to form a self-setting calcium phosphate cement from the powder mixture. This cement can be used as bone filler or bone substitute in applications, which require higher rates of resorption.

La présente invention a pour objet une nouvelle poudre de ciment au phosphate de calcium, dont la composition peut être mieux décrite par un rapport molaire Ca/P de 1,35 à 1,40, de préférence de 1,39, et dont les deux composants ont été préparés en suivant des procédures de sysnthèse chimique en milieu humide. Un des composants est une poudre biphasique alpha-TCP (Ca3(PO4)2, 95 % en poids) + HA (Ca10(PO4)6(OH)2, 5 % en poids) synthétisée chimiquement, alors que le deuxième composant est une poudre uniphase DCPD (CaHPO4.2H2O) également synthétisée chimiquement. Une solution décantable (Na2HPO4.2H2O) est utilisée pour former un ciment de phosphate de calcuium auto-décantable à partir du mélange de poudres. Ce ciment peut être utilisé comme matière de charge pour os ou comme substitut d'os dans des applications qui nécessitent des taux de résorption plus élevés.

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