C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2441706
The present invention relates to a new essential downstream component of the wingless signaling pathway. In particular, the invention relates to nucleotide sequences of the Drosophila melanogaster daughter of legless (doll) gene, of its encoded proteins, as well as derivatives, fragments and analogues thereof. The invention includes vertebrate and invertebrate homologues of the Doll protein, comprising proteins that contain a stretch of amino acids with similarity to the Drosophila Doll gene. Methods for producing the Doll protein, derivatives and analogs, e.g. by recombinant means, and antibodies to Doll are provided by the present invention as well. The invention also relates to methods for performing high throughput screening assays for compounds modulating Doll function in the Wnt pathway.
La présente invention concerne un nouveau composant aval essentiel du chemin de signalisation des aptères. L'invention concerne plus particulièrement des séquences de nucléotides du gène Doll (daugther of legless) de Drosophila melanogaster, de ses protéines codées, ainsi que certains de ses dérivés, fragments et analogues. L'invention concerne également des homologues vertébrés et invertébrés de la protéine Doll, y-compris des protéines qui contiennent une extension d'acides aminés présentant une similitude avec le gène Doll de la drosophile. L'invention concerne aussi des procédés de production de la protéine Doll, de ses dérivés et analogues, notamment par recombinaison, et des anticorps du Doll. L'invention concerne enfin des procédés permettant de réaliser des essais par criblage à haut rendement portant sur des composés modulateur de la fonction Doll dans le chemin Wnt.
Basler Konrad
Kramps Thomas
Marks & Clerk
Universitaet Zuerich
LandOfFree
A new essential downstream component of the wingless... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with A new essential downstream component of the wingless..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A new essential downstream component of the wingless... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1807385