A new family of compounds having anti-inflammatory and...

C - Chemistry – Metallurgy – 07 – C

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C07C 259/06 (2006.01) A61K 31/195 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) C07D 207/46 (2006.01) C07D 211/94 (2006.01) C07D 223/10 (2006.01)

Patent

CA 2231996

A new family of compounds having anti-inflammatory, anti-viral, and broncho- dilating activity having linear formula (I) and cyclic formula (II), and compositions of these, which alone, and in combination with reverse transcriptase inhibitors thereby resulting in an additive or synergistic effect, are useful in inhibiting or suppressing viruses including those exhibiting retroviral replication, or eliminating viruses including a retrovirus such as HIV in a human cell population and methods of using these compositions, compounds, and salts thereof.

Cette invention se rapporte à une nouvelle famille de composés présentant une activité anti-inflammatoire, anti-virale et broncho-dilatatoire. Ces composés sont représentés par la formule linéaire (I) et par la formule cyclique (II). L'invention se rapporte également à des compositions contenant de tels composés, utilisés soit seuls soit associés à des inhibiteurs de transcriptase inverse qui permettent à ces compositions de produire un effet additif ou synergique. Ces compositions s'avèrent utiles pour inhiber ou supprimer des virus, y compris les virus présentant une réplication rétrovirale, ou éliminer des virus, notamment un rétrovirus du type VIH, dans une population de cellules humaines. L'invention se rapporte en outre à des procédés d'utilisation de ces compositions, de ces composés et de leurs sels.

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