A new physically stable solid form of a fluoroquinolone

Details A new physically stable solid form of a fluoroquinolone A new physically stable solid form of a fluoroquinolone

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2201735

Novel crystal forms of the fluoroquinolone, [S-(R*,S*)]-1-cyclopropyl-6-fluoro- 1,4-dihydro-8-methoxy-7-[3-[1-(methylamino)ethyl]-1-pyrrolidinyl]-4-oxo-3- quinolinecarboxylic acid are disclosed. The forms are characterized by one methanol solvate form, and three anhydrous polymorphic forms, of which, Form III exhibits greatest stability and decreased hygroscopicity.

L'invention concerne de nouvelles formes cristallines d'une fluoroquinolone appelée acide [S-(R*,S*)]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-méthoxy-7-[3-[1-(méthylamino)éthyl]-1-pyrrolidinyl]-4-oxo-3-quinoléine carboxylique. Les formes sont caractérisées par une forme qui est un solvate de méthanol et trois formes polymorphes anhydres, dont la forme III présente la stabilité la plus grande et l'hygroscopicité la plus faible.

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