A new process for the preparation of epothilone derivatives,...

Details A new process for the preparation of epothilone derivatives,... A new process for the preparation of epothilone derivatives,...

C - Chemistry, Metallurgy

07

D

C07D 493/04 (2006.01) A61P 35/00 (2006.01) C07D 275/06 (2006.01) C07D 303/14 (2006.01) C07D 303/16 (2006.01) C07D 303/18 (2006.01)

Patent

CA 2497119

The present invention provides a synthesis for the preparation of epothilone derivatives of formula (9) wherein R1 is methyl, and R2 has the meaning of an unsubstituted or substituted aryl, an unsubstituted or substituted heteroaryl or an unsubstituted or substituted heterocyclic radical fused to a benzene nucleus, and salts thereof, and intermediates for the synthesis of a compound of formula (9).

L'invention concerne la synthèse de dérivés de l'épothilone représentés par la formule (9), dans laquelle R1 représente méthyle, et R2 représente aryle substitué ou non substitué, hétéroaryle substitué ou non substitué ou un radical hétérocyclique condensé à un cycle benzénique, des sels de ceux-ci, ainsi que des intermédiaires servant à la synthèse d'un composé représenté par la formule (9).

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