A new regime for paclitaxel in kaposi's sarcoma patients

A - Human Necessities – 61 – K

Patent

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A61K 31/335 (2006.01) A61K 31/337 (2006.01)

Patent

CA 2189916

This invention provides for novel dose regimen of paclitaxel to treat Kaposi's sarcoma. Unlike current paclitaxel therapy protocols, the claimed dosages are lower yet surprisingly as effective in regression of KS tumors. In addition, the lower doses are accompanied with fewer incidents of undesired side effects. The effectiveness of low doses of paclitaxel as well as fewer and less debilitating side effects, makes this therapy protocol the first that can be used for long term and as maintenance therapy in the management of patients with Kaposi's sarcoma.

Divulgation d'une nouvelle posologie du paclitaxel pour le traitement du sarcome de Kaposi. Contrairement aux protocoles thérapeutiques actuels avec le paclitaxel, les doses revendiquées sont inférieures, bien que curieusement aussi efficaces pour faire régresser les tumeurs du SK. En outre, on signale moins de cas d'effets secondaires indésirables avec des doses moins fortes. L'efficacité d'une dose plus faible de paclitaxel, conjuguée à des effets secondaires moins fréquents et moins débilitants, fait de ce protocole thérapeutique le premier pouvant être suivi pour une thérapie à long terme et d'entretien chez les patients atteints du sarcome de Kaposi.

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