C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/48 (2006.01) C12Q 1/18 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2255460
The present invention relates to a method to design antibiotics, which comprises testing of compounds which inhibit bacterial cell division by blocking the s-adenosylmethionine-dependent step of formation of crosswall during cell division in bacteria and other microorganism. The S-adenosylmethionine-dependent step is catalyzed by the product of the yabC gene (accession number COO2042, orf B) of Escherichia coli. This gene has been cloned, together with the first gene of the same operon, yabB (accession number COO2041, orfC). Overproduction and underproduction of the yabC gene product is toxic to E. coli. Compounds which induce or repress the promoter of the yabBC, or increase production of the yabC gene product, as well as inhibitors of the yabC S-adenosylmethionine-dependent methylase will act as antibiotics.
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