A non-destructive method to quantify and isolate...

Details A non-destructive method to quantify and isolate... A non-destructive method to quantify and isolate...

A - Human Necessities

61

K

A61K 39/00 (2006.01) C07K 16/00 (2006.01) C12N 5/00 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2719522

The present invention relates to antigen-Ig Ab fusion molecules and methods of using same, wherein antigen-Ig Ab fusion molecules include an antigen fused to an immunoglobulin molecule, fragment or variant thereof and wherein the fusing of the immunoglobulin molecule to the antigen does not alter the specificity or tertiary structure of important epitopes of the antigen. This method allows the direct quantification and isolation of antigen-specific B cells by flow cytometry in essentially any species.

Cette invention se rapporte à des molécules de fusion antigène-Ig et à leurs procédés d'utilisation, lesdites molécules de fusion antigène-Ig comprenant un antigène fusionné avec une molécule d'immunoglobuline, son fragment ou son variant, la fusion de la molécule d'immunoglobuline avec l'antigène ne modifiant pas la spécificité ou la structure tertiaire d'épitopes importants de l'antigène. Ce procédé permet de quantifier et d'isoler directement les lymphocytes B spécifiques d'un antigène par cytométrie en flux chez sensiblement toutes les espèces.

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