A non-invasive assay for the assessment of functioning...

G - Physics – 01 – N

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G01N 33/497 (2006.01) A61K 49/00 (2006.01) A61K 51/00 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2526031

The present invention relates to a diagnostic method for assessing the functioning and/or structural integrity of the gut in animal subjects. The method of the present invention is predicated on assessing the absorption and/or metabolism of one or more test sugars or functional equivalents such as phosphorylated sugars, oligopeptides or oligonucleotides in an animal subject, wherein the level and/or rate of absorption or metabolism of each molecule is examined to give an overall indication of gut functioning and/or gut structural integrity in the animal subject. The methods of the present invention have inter alia medical and diagnostic applications in humans, such as for the diagnosis of various pathologies associated with changes in gut function or permeability. Furthermore, the methods of the present invention may also be applied to assess gut function or structural integrity in other animal, including avian, species.

L'invention concerne une méthode de diagnostic permettant d'évaluer le fonctionnement et/ou l'intégrité structurale de l'intestin chez les sujets animaux. Cette méthode repose sur l'évaluation de l'absorption et/ou du métabolisme d'un ou de plusieurs glucides examinés ou de leurs équivalents fonctionnels tels que sucres phosphorylés, oligopeptides ou oligonucléotides chez un sujet animal, et consiste à contrôler le niveau et/ou la vitesse d'absorption ou de métabolisme de chaque molécule afin d'obtenir une indication générale du fonctionnement de l'intestin et/ou de l'intégrité structurale de l'intestin chez ce sujet animal. Les méthodes décrites ont notamment des applications médicales et diagnostiques chez les sujets humains, par exemple pour le diagnostic de diverses pathologies associées à des modifications de la fonction ou de la perméabilité intestinale. Ces méthodes peuvent en outre servir à évaluer la fonction ou l'intégrité structurale de l'intestin chez d'autres espèces animales, notamment chez les oiseaux.

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