C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2476835
The present invention relates to the use of antibodies directed against specific histone amino terminus modifications as diagnostic indicators of disease or congenital defects. In one embodiment, nucleosomes are isolated from a blood or serum sample of a patient using histone specific antibodies and the accompanying DNA is purified and analyzed for diagnostic and screening purposes.
L'invention concerne l'utilisation d'anticorps dirigés contre des modifications spécifiques des extrémités N-terminales de l'histone utilisées comme indicateurs diagnostiques de maladies ou d'anomalies congénitales. Dans un mode de réalisation, des nucléosomes sont isolés d'un échantillon de sang ou de sérum d'un patient, au moyen d'anticorps spécifiques de l'histone et l'ADN associé est purifié et analysé aux fins de diagnostic et de criblage.
Allis C. David
Bruns David E.
Drummond Alan H.
Chroma Therapeutics Ltd.
Sim & Mcburney
University Of Virginia Patent Foundation
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