C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) C07K 1/22 (2006.01) C07K 14/475 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2091700
The present invention relates to a novel truncated form of hepatocyte growth factor (HGF) which specifically antagonizes the activity of HGF. In particular, the present invention relates to the purification, molecular cloning and recombinant expression of the truncated HGF variant. The present invention further relates to the utilization of the small HGF variants in the diagnosis and treatment of diseases in which cell proliferation is either excessive as in the case of malignancy or impaired due in part to aberrant expression of the various forms of HGF.
Aaronson Stuart A.
Bottaro Donald P.
Chan Andrew M.-L.
Rubin Jeffrey S.
Mccarthy Tetrault Llp
The United States Of America As Represented By The Secretary Dep
U.s. Departm Ent Of Commerce The United States Of America Represented By The Secretary
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