A non-surgical method for preventing or reducing the rate of...

A - Human Necessities – 61 – K

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A61K 38/48 (2006.01) A61K 9/00 (2006.01) A61K 47/00 (2006.01) A61P 27/02 (2006.01) C12N 9/68 (2006.01)

Patent

CA 2607181

A non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy to the proliferative form of diabetic retinopathy comprising intravitreally administering to a patient suffering from non-proliferative diabetic retinopathy an effective amount of serine proteinase enzyme sufficient to create, without surgery, a posterior vitreal detachment to prevent or reduce the progression of proliferative diabetic retinopathy in said patient. Also disclosed is a non-surgical method of treating ocular conditions such as retinal ischemia, retinal inflammation, retinal edema tractional retinal detachment, tractional retinopathy, vitreous hemorrhage and tractional maculopathy by intravitreally administering to a patient suffering from one or more of these conditions with an effective amount of a serine proteinase enzyme to reduce or treat that particular ocular condition. Plasmin, microplasmin and miniplasmin are preferred serine proteinase enzymes and plasmin is the most preferred.

L'invention concerne une méthode non chirurgicale permettant de prévenir ou de ralentir l'évolution de la rétinopathie diabétique non proliférative vers la forme proliférative de rétinopathie diabétique, consistant à administrer par voie intravitréenne à un patient souffrant d'une rétinopathie diabétique non proliférative une dose de sérine protéinase suffisante pour créer, sans chirurgie, un détachement du vitré postérieur, afin d'empêcher ou de ralentir la progression de la rétinopathie diabétique proliférative chez ledit patient. L'invention concerne également une méthode non chirurgicale permettant de traiter des troubles oculaires tels que l'ischémie rétinienne, les inflammations de la rétine, l'oedème rétinien, le décollement de rétine par traction, les rétinopathies tractionnelles, les hémorragies vitréennes, et la maculopathie tractionnelle, par l'administration intravitréenne à un patient présentant une ou plusieurs de ces affections d'une dose suffisante de sérine protéinase pour réduire ou traiter cette affection oculaire particulière. Les sérine protéinases indiquées sont la plasmine, la microplasmine, et la miniplasmine, la plasmine étant la préférée.

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