A novel and efficient method for the synthesis of an amino acid

Details A novel and efficient method for the synthesis of an amino acid A novel and efficient method for the synthesis of an amino acid

C - Chemistry, Metallurgy

07

C

C07C 227/04 (2006.01) A61K 31/197 (2006.01) A61P 25/00 (2006.01) C07C 205/15 (2006.01) C07C 205/51 (2006.01) C07C 229/08 (2006.01)

Patent

CA 2723871

The present invention relates to a novel process for the preparation of .gamma.-amino acids, such 5 as (~)-3-(aminomethyl)-5-methyl-hexanoic acid (1), which is a key intermediate in the preparation of the potent anticonvulsant pregabalin, (S)-(+)-3-(aminomethyl)-5-methyl- hexanoic acid (2), and its analogues.

La présente invention porte sur un nouveau procédé pour la préparation de ?-aminoacides, tels que l'acide (±)-3-(aminométhyl)-5-méthyl-hexanoïque (1), qui est un intermédiaire clé dans la préparation de la prégabaline anticonvulsive puissante, l'acide (S)-(+)-3-(aminométhyl)-5-méthyl-hexanoïque (2), et leurs analogues.

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