C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2383871
The present invention is directed to BAP28 polypeptides, BAP28 cDNA sequences encoding BAP28 polypeptides, to the genomic DNA sequence of the BAP28 gene as well as to regulatory regions located at the 5'- and 3'-ends of the BAP28 coding region. The invention also deals with antibodies directed specifically against such polypeptides that are useful as diagnostic reagents. The invention further encompasses biallelic markers of the BAP28 gene useful in genetic analysis. The invention concerns an association of the BAP28-related biallelic markers with prostate cancer. Therefore, the invention contemplates the diagnostic and treatment methods of prostate cancer.
La présente invention concerne des polypeptides BAP28, des séquences d'ADNc BAP28 codant pour les polypeptides BAP28, la séquence d'ADN génomique du gène BAP28, ainsi que les régions régulatrices situées aux extrémités 5' et 3' de la région codante de BAP28. L'invention concerne également des anticorps spécifiquement dirigés contre ces polypeptides, utilisés comme réactifs diagnostiques. L'invention concerne en outre des marqueurs bialléliques du gène BAP28, utilisés dans l'analyse génétique. L'invention concerne enfin l'association entre les marqueurs bialléliques liés au BAP28 et le cancer de la prostate. L'invention concerne, par conséquent, des méthodes de diagnostic et de traitement du cancer de la prostate.
Barry Caroline
Bougueleret Lydie
Chumakov Ilya
Cohen-Akenine Annick
Genset S.a.
Serono Genetics Institute S.a.
Sim & Mcburney
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