A novel binding site for retigabine on kcnq5

Details A novel binding site for retigabine on kcnq5 A novel binding site for retigabine on kcnq5

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01)

Patent

CA 2634221

Disclosed herein are nucleic acid and polypeptide sequences of mutated KCNQ5 potassium channels which lack responsiveness to the potassium channel activator retigabine. Also disclosed herein are methods and kits related to the use of the aforementioned mutated KCNQ5 potassium channels.

L'invention concerne des séquences polypeptidiques et d'acides nucléiques de canaux potassiques KCNQ5 mutés manquant de réactivité face à la rétigabine d'activation de canaux potassiques. L'invention concerne également des méthodes et des trousses associées à l'utilisation des canaux potassiques KCNQ5 mutés susmentionnés.

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