A novel biological substance nesfatin and its related...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/16 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 3/04 (2006.01) C07K 14/47 (2006.01) C07K 14/575 (2006.01) C07K 16/18 (2006.01) C07K 16/26 (2006.01) C12N 15/00 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2613257

A novel method for obtaining a factor involved in the control of food intake and/or body weight; a gene produced by the method, a polypeptide encoded by the gene or a novel peptide produced based on the information on the polypeptide encoded by the gene for use as a means for the treatment/control/diagnosis of a disease involving the eating disorder and/or body weight control; and a substance capable of inhibiting the action of the gene or polypeptide for use as a means for the treatment/control/diagnosis of a disease involving the control of food intake and/or body weight. A gene or polypeptide involved in the suppression of food intake and/or decrease in body weight can be produced by using a thiazolidione having a PPAR.gamma.-agonistic activity. NESFATIN or the like produced by the method can be used as a means for the treatment/control/diagnosis of a disease involving the eating disorder and/or body weight control.

La présente invention concerne un procédé innovant permettant d'obtenir un facteur impliqué dans la régulation de l'absorption de nourriture et/ou du poids corporel ; un gène produit par le procédé ; un polypeptide codé par le gène ou un peptide innovant produit sur la base des informations relatives au polypeptide codé par le gène utilisable comme moyen de traitement de lutte ou de diagnostic pour une maladie impliquant le trouble du comportement alimentaire et/ou comme moyen de régulation du poids corporel ; et une substance capable d'inhiber l'action du gène ou du polypeptide utilisable comme moyen de traitement de lutte ou de diagnostic pour une maladie impliquant le trouble du comportement alimentaire et/ou comme moyen de régulation du poids corporel. Un gène ou un polypeptide impliqué dans la suppression de l'absorption de nourriture et/ou dans la diminution du poids corporel peut être produit en utilisant une thiazolidione ayant une activité agoniste de PPAR.gamma.. La NESFATINE ou un produit similaire produit par le procédé peut être utilisé comme moyen de traitement de lutte ou de diagnostic pour une maladie impliquant le trouble du comportement alimentaire et/ou comme moyen de régulation du poids corporel.

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