A novel cationic lipopolymer as a biocompatible gene...

Details A novel cationic lipopolymer as a biocompatible gene... A novel cationic lipopolymer as a biocompatible gene...

A - Human Necessities

61

K

A61K 9/127 (2006.01)

Patent

CA 2539169

A biodegradable cationic lipopolymer comprising a polyethylenimine (PEI), a lipid, and a biocompatible hydrophilic polymer, wherein 1) the lipid and the biocompatible hydrophilic polymer are directly linked to the PEI backbone or 2) the lipid is linked to the PEI backbone through the biocompatible hydrophilic polymer. The cationic lipopolymers of the present invention can be used for delivery of a nucleic acid or any anionic bioactive agent to various organs and tissues after local or systemic administration.

Cette invention se rapporte à un lipopolymère cationique biodégradable comprenant une plyéthylène-imine (PEI), un lipide, et un polymère hydrophile biocompatible, où (1) le lipide et le polymère hydrophile biocompatible sont directement liés au squelette de la PEI ou (2) le lipide est lié au squelette de la PEI par l'intermédiaire du polymère hydrophile biocompatible. Les lipopolymères cationiques faisant l'objet de cette invention peuvent être utilisés pour l'apport d'un acide nucléique ou d'un quelconque agent bioactif anionique dans divers organes et tissus après administration locale ou systémique.

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