C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01)
Patent
CA 2557597
The invention provides a new glucocorticoid receptor coactivator named STAMP (SRC-1 and TIF2 Associated Modulatory Protein) that can modulate transcription of glucocorticoid-responsive genes. The invention also provides antibodies that can bind STAMP and modulate its activity. In addition, the invention provides antisense, ribozyme and siRNA STAMP nucleic acids that can modulate the expression of STAMP. Also provided are compositions and methods for modulating glucocorticoid-responsive gene expression and for treating a variety of diseases and conditions.
L'invention concerne un nouveau coactivateur du récepteur des glucocorticoïdes désigné sous le nom de STAMP (protéine modulatrice associée au SRC-1 et au TIF2), pouvant moduler la transcription des gènes sensibles aux glucocorticoïdes. L'invention concerne également des anticorps de liaison au STAMP et de modulation de l'activité de celui-ci. L'invention concerne, de plus, des acides nucléiques STAMP antisens, à activité ribozyme et ARNsi pouvant moduler l'expression du STAMP. L'invention concerne également des compositions et des méthodes de modulation de l'expression des gènes sensibles aux glucocorticoïdes, et de traitement d'une diversité de maladies et d'états pathologiques.
He Yuanzheng
Simons S. Stoney Jr.
Smart & Biggar
The Government Of The United States Of America As Represented By The Se Cretary Of The Department Of Health And
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