C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/64 (2006.01) C07K 14/81 (2006.01) C07K 16/38 (2006.01) C07K 16/40 (2006.01) C12Q 1/37 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2365540
The present invention provides a novel complex of hK2 and PI-6 and methods of using the novel complex. The novel complexes of hK2 and PI-6 of the present invention exist at an elevated level in prostat cancer tissues. Therefore, the hK2-PI6 complexes of the present invention may be used as a serum marker for detecting prostate cancer. They may also be used as an immunohistological marker to detect prostate cancer tissues. In accordance with the present invention, the hK2-PI6 complexes of the present invention may be detected in patient tissue samples by immunohistochemical and/or in patient fluid samples by in vitro immunoassay procedures. Diagnostic kits and diagnostic methods for detecting the existence of prostate cancer are also provided.
L'invention concerne un nouveau complexe de hK2 et PI-6 et ses procédés d'utilisation. Les nouveaux complexes de hK2 and PI-6 existent en proportion élevée dans les tissus cancéreux prostatiques. Ainsi, les complexes hK2-PI6 de l'invention peuvent être utilisés comme marqueur sériques pour la détection du cancer de la prostate. Ils peuvent également être utilisés comme marqueur immunohistologique pour la détection de tissus cancéreux prostatiques. Selon l'invention, les complexes hK2-PI6 peuvent être détectés dans des échantillons de tissus d'un patient par immunohistochimie et/ou dans des échantillons de liquides du patient par des procédures de dosage immunologique in-vitro. Des kits de diagnostic et des méthodes diagnostiques pour la détection de l'existence du cancer de la prostate sont également décrits.
Mikolajczyk Stephen D.
Saedi Mohammad S.
Hybritech Incorporated
Macrae & Co.
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