A novel component of the wg/wnt signaling pathway

Details A novel component of the wg/wnt signaling pathway A novel component of the wg/wnt signaling pathway

C - Chemistry, Metallurgy

07

K

C07K 14/475 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2600540

The present invention relates to a novel component of the Wg/Wnt signaling pathway. In particular, the invention relates to nucleic acid molecule being homologue to the sequence of the gene CG6210 (Drosophila melanogaster), of its encoded polypeptide named 3L3 or WLS, as well as derivatives, fragments and analogues thereof. The invention relates to methods for screening for a substance that inhibits or enhances the secretion of a protein of the Wnt- family as well as to antibodies binding to said (poly)peptides.

L'invention porte: sur un nouveau composant du mécanisme de signalisation wg/wnt et en particulier sur une molécule d'acide nucléique homologue de la séquence du gène CG6210 (Drosophila melanogaster); sur un polypeptide codé par lui, dit 3L3 ou WLS; et sur ses dérivés, fragments et analogues. L'invention porte également sur des méthodes de criblage d'une substance inhibant ou accroissant la sécrétion d'une protéine de la famille Wnt et sur des anticorps se fixant auxdits (poly)peptides.

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