A novel composition for controlled and sustained transdermal...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/70 (2006.01) A61K 31/565 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61L 15/58 (2006.01)

Patent

CA 2247767

A patch for transdermal administration of drugs through controlled release system, consisting essentially of: A) a flexible backing layer; B) an adhesive layer comprising: - an adhesive pressure sensitive adhesive polymeric matrix, - a cohesion improver, - a tackifier agent, - a combination of permeation enhancers consisting of a first component which is a saturated fatty acid or fatty alcohol represented by the formula CH3-(CH2)n-COOH or CH3-(CH2)n-CH2OH respectively, in which n is an integer from 6 to 16, and of a second component which is a monounsaturated fatty acid or fatty alcohol represented by the formula CH3-(CnH2(n-1))-COOH or CH3-(CnH2(n-1))-CH2OHrespectively, in which n is an integer from 8 to 22, with the provision that the chain lenght of the first component is different from that of the second component, C) a protective liner, which is removed at the moment of use.

Bande adhésive pour l'administration transdermique de médicaments par un système à libération contrôlée, constituée principalement : A) d'une couche d'appui flexible; B) d'une couche adhésive renfermant une matrice polymérique adhésive autocollante, un agent améliorant l'adhérence, un agent collant, une combinaison d'agents améliorant la perméation - comprenant un premier constituant, à savoir un acide gras saturé ou un alcool gras, représentés respectivement par les formules CH3-(CH2)n-COOH ou CH3-(CH2)n-CH2OH, dans lesquelles n est un entier de 6 à 16, et un second constituant, à savoir un acide gras mono-insaturé ou un alcool gras, représentés respectivement par la formule CH3-(CnH2(n-1))-COOH ou CH3-(CnH2(n-1))-CH2OH, dans lesquelles n est un entier de 8 à 22, à la condition que la longueur de chaîne du premier constituant soit différente de celle du second; C) d'un revêtement protecteur, que l'on enlève au moment de l'utilisation.

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