C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 209/00 (2006.01) C07D 239/00 (2006.01)
Patent
CA 2400155
The invention relates to the field of pharmaceutical and organic chemistry and provides an improved process for preparing the novel heptahydrate crystalline salt of multitargeted antifolate N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]- pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid.
L'invention relève du domaine de la chimie pharmaceutique et organique, et concerne un meilleur procédé de préparation d'un nouveau sel cristallin heptahydrate de l'antifolique multicible N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]-pyrimidin-5-yl)éthyl]benzoyl]-L-acide glutamique.
Chelius Erik Christopher
Reutzel-Edens Susan Marie
Snorek Sharon Van Den Berghe
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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