A novel endothelial cell molecule mediating lymphocyte...

Details A novel endothelial cell molecule mediating lymphocyte... A novel endothelial cell molecule mediating lymphocyte...

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/18 (2006.01) G01N 33/564 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2137551

A novel endothelial cell molecule, VAP-1, that mediates lymphocyte binding in man, is described. Anti-VAP-1 monoclonal antibodies are described and the monoclonal antibody 1B2 is provided by this invention, as well as the hybridoma cell line (DSM ACC2041) which produces it. This invention further provides methods for the treatment of inflammatory and autoimmune dis- eases by the administration of VAP-1 binding compounds, such as anti-VAP-1 antibodies.

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