A novel engineered superantigen for human therapy

Details A novel engineered superantigen for human therapy A novel engineered superantigen for human therapy

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/31 (2006.01) C07K 14/315 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2451847

The present invention relates to compositions and methods of use, wherein the composition comprises a conjugate of a bacterial superantigen and an antibody moiety. More particularly, the bacterial superantigen has been modified to decrease seroreactivity with retained superantigen activity.

L'invention concerne des compositions et des méthodes d'utilisation, dans lesquelles les compositions comprennent un conjugué d'un superantigène bactérien et une entité anticorps. Plus particulièrement, le superantigène bactérien a été modifié afin de diminuer la réactivité sérologique avec maintien de son activité.

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