A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/46 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61K 9/54 (2006.01) A61K 9/66 (2006.01)
Patent
CA 2579177
The present invention is directed to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a gastrointestinal disorder or disease, or the symptoms associated with, or related to a gastrointestinal disorder or disease in a subject in need thereof. In one aspect, the present invention provides a pharmaceutical composition comprising a proton pump inhibiting agent and a buffering agent for oral administration to a subject. Upon administration, the composition contacts the gastric fluid of the stomach and increases the gastric fluid pH of the stomach to a pH that substantially prevents or inhibits acid degradation of the proton pump inhibiting agent in the gastric fluid and allows a measurable serum concentration of the proton pump inhibiting agent to be absorbed into the blood serum of the subject.
L'invention concerne des procédés, des kits, des combinaisons, ainsi que des compositions de traitement, de prévention ou de réduction du risque de développement d'un trouble ou d'une maladie gastro-intestinale, ou de symptômes associés ou relatifs à un trouble ou une maladie gastro-intestinale chez un sujet. Dans un premier aspect, l'invention concerne une composition pharmaceutique qui contient un inhibiteur de la pompe à protons et un agent tampon, et qui est administrée oralement au sujet. Après administration, la composition entre en contact avec le suc gastrique dont elle augmente le pH pour obtenir un pH qui empêche ou inhibe sensiblement la dégradation par l'acide de inhibiteur de la pompe à protons dans le suc gastrique, et qui permet l'absorption d'une concentration sérique mesurable de l'inhibiteur de la pompe à protons par le sérum sanguin du sujet.
Goldlust Barry
Hepburn Bonnie
Gowling Lafleur Henderson Llp
Santarus Inc.
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