A novel formulation, omeprazole antacid complex-immediate...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/24 (2006.01) A61K 9/26 (2006.01) A61K 9/28 (2006.01) A61K 9/30 (2006.01) A61K 9/42 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2517005

The present invention is directed to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a gastrointestinal disorder or disease, or the symptoms associated with, or related to a gastrointestinal disorder or disease in a subject in need thereof. In one aspect, the present invention provides a pharmaceutical composition comprising a proton pump inhibiting agent and a buffering agent for oral administration and ingestion by a subject. Upon administration, the composition contacts the gastric fluid of the stomach and increases the gastric fluid pH of the stomach to a pH that substantially prevents or inhibits acid degradation of the proton pump inhibiting agent in the gastric fluid and allows a measurable serum concentration of the proton pump inhibiting agent to be absorbed into the blood serum of the subject.

L'invention concerne des méthodes, des trousses, des combinaisons et des compositions pour traiter, pour prévenir, et pour réduire le risque de développement d'un trouble ou d'une maladie gastro-intestinale, ou de symptômes associés à ceux-ci, ou associés à un trouble ou à une maladie gastro-intestinale, chez un patient nécessitant ce traitement. Dans un aspect de l'invention, l'invention concerne une composition pharmaceutique comprenant un agent inhibant une pompe protonique et un agent tampon pour une administration et pour une ingestion orale par un patient. Lors de l'administration, la composition entre en contact avec le fluide gastrique de l'estomac et augmente le pH du fluide gastrique de l'estomac pour atteindre un pH permettant d'éliminer ou d'inhiber sensiblement une dégradation acide de l'agent d'inhibition de pompe protonique du fluide gastrique, et permettant d'absorber une concentration de sérum mesurable de l'agent d'inhibition de pompe protonique dans le sérum sanguin du patient.

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