A novel fungal multisubunit protein complex critical for...

Details A novel fungal multisubunit protein complex critical for... A novel fungal multisubunit protein complex critical for...

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 45/06 (2006.01) C07K 14/37 (2006.01) C07K 14/395 (2006.01) C12N 15/67 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2199748

Identification of yeast TATA-box-binding protein (TBP) associated factors (TAFs). Use of TBP as a protein-affinity ligand to isolate from yeast a multisubunit complex that is required specifically for activated transcription by RNA polymerase II.

L'invention concerne l'identification de facteurs (TAF) associés à la protéine (TBP) de liaison de la séquence TATA propre aux levures, ainsi que l'utilisation de cette protéine (TBP) de liaison en tant que ligand présentant une affinité pour les protéines, pour isoler à partir de levures un complexe à sous-unités multiples qui est spécifiquement nécessaire pour la transcription activée par l'ARN polymérase II.

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