C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 45/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2462424
Novel GAVE10 polypeptides, proteins and nucleic acid molecules are provided. In addition to isolated, full-length GAVE10 proteins, isolated GAVE10 fusion proteins, antigenic peptides and anti-GAVE10 antibodies are taught. GAVE10, recombinant expression vectors, host cells into that the expression vectors have been introduced and non-human transgenic animals in that a GAVE10 gene has been introduced or disrupted are taught. Diagnostic, screening and therapeutic methods utilizing compositions of the invention also are provided.
L'invention concerne de nouveaux polypeptides, protéines et molécules d'acide nucléique GAVE10. Elle concerne aussi des protéines GAVE10 pleine longueur isolées, des protéines hybrides GAVE10 isolées, des peptides antigéniques et des anticorps anti-GAVE10. L'invention concerne également des vecteurs d'expression recombinés, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits, et des animaux transgéniques non humains dans lesquels un gène GAVE10 a été introduit ou interrompu. L'invention concerne en outre des méthodes de diagnostic, de criblage et de thérapie mettant en oeuvre des compositions de l'invention.
Ardati Ali
Cai Jidong
Eishingdrelo Haifeng
Aventis Pharmaceuticals Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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