A novel g protein-coupled receptor, gave8

Details A novel g protein-coupled receptor, gave8 A novel g protein-coupled receptor, gave8

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 45/00 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2454427

Novel GAVE8 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length GAVE8 proteins, isolated GAVE8 fusion proteins, antigenic peptides and anti-GAVE8 are provided.The invention also provides GAVE8 nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecule, host cells into which the expression vectors have been introduced and nonhuman transgenic animals in which GAVE8 gene has been introduced or disrupted are described. Diagnostic, screening, and therapeutic methods utilizing GAVE8 compositions or molecules binding GAVE8 also are provided. Methods for identifying GAVE8 agonists, antagonists, inverse agonists and the like are described.

L'invention concerne de nouveaux polypeptides, des protéines et des molécules d'acide nucléique GAVE8. L'invention concerne également des protéines GAVE8 pleine longueur isolées, des protéines hybrides GAVE8 isolées, des peptides antigéniques et des anticorps anti-GAVE8. L'invention concerne également des molécules d'acide nucléique GAVE8, des vecteurs d'expression recombinés contenant cette molécule d'acide nucléique, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits et des animaux transgénique non humains dans lesquels le gène GAVE8 a été introduit ou interrompu. L'invention concerne également des méthodes de diagnostic, de criblage et de thérapie faisant intervenir des compositions ou des molécules GAVE8 fixant GAVE8. L'invention concerne également des méthodes destinées à l'identification d'agonistes, d'antagonistes, d'agonistes inverses de GAVE8 et d'éléments analogues.

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