A novel growth factor and a genetic sequence encoding same

Details A novel growth factor and a genetic sequence encoding same A novel growth factor and a genetic sequence encoding same

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2214439

The present invention relates generally to an isolated molecule having vascular endothelial growth factor-like properties and to a genetic sequence encoding same. The molecule will be useful in the development of a range of therapeutics and diagnostics useful in the treatment, prophylaxis and/or diagnosis of conditions requiring enhanced or diminished vasculature and/or vascular permeability. The molecule of the present invention is also a useful effector of primary and central neurons and is capable of inducing astroglial proliferation.

Cette invention se rapporte d'une façon générale à une molécule isolée ayant des propriétés similaires à celles du facteur de croissance endothéliale vasculaire, ainsi qu'à une séquence génétique codant cette molécule. Cette molécule peut servir dans la mise au point d'une large game d'agents thérapeutiques et diagnostiques utiles dans le traitement, la prophylaxie et/ou le diagnostic d'états nécessitant une vascularisation et/ou une perméabilité vasculaire accrues ou diminuées. La molécule faisant l'objet de cette invention est également utile comme agent effecteur de neurones primaires et centraux et elle est capable d'induire la prolifération astrogliale.

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