A novel heteromultimeric ion channel receptor and uses thereof

Details A novel heteromultimeric ion channel receptor and uses thereof A novel heteromultimeric ion channel receptor and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7052 (2006.01) A61K 38/17 (2006.01) A61K 45/06 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 5/12 (2006.01) C12N 15/66 (2006.01) C12Q 1/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2304494

The present invention describes a novel heteromultimeric proton-gated ion channel (herein called ASIC-2S.2) with distinctive properties. Compositions and methods are provided for producing and expressing functional ASIC-2S.2 channels, composed of ASIC2A and ASIC3 subunits. The invention also provides genetically engineered expression vectors comprising the nucleic acid sequences encoding both ASIC2A and ASIC3 and host cells coexpressing both ASIC2A and ASIC3 subunits. Also provided herein are genetically engineered nucleic acids encoding chimeric proton-gated ion channels comprised of at least two different subunits, as well as expression vectors and host cells comprising said engineered nucleic acids. The invention also provides for the use of ASIC-2S.2, as well as agonists, antagonists or antibodies specifically binding ASIC-2S.2, in the diagnosis, prevention and treatment of diseases associated with expression of ASIC- 2S.2. Also are disclosed methods of influencing electrophysiological, pharmacologi- cal and/or functional properties of ASIC-2S.2 as well as methods for screening for substances having ion-channel modulating activity or substances capable of disrupting subunit association or interaction..

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