A novel human g-protein coupled receptor hcept09

Details A novel human g-protein coupled receptor hcept09 A novel human g-protein coupled receptor hcept09

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2231754

HCEPT09 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HCEPT09 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma, Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Hungtington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

Divulgation de polypeptides et de polynucléotides HCEPT09, ainsi que de méthodes de production de tels polypeptides par des techniques de recombinaison. Des méthodes sont également dévoilées pour utiliser les polypeptides et polynucléotides HCEPT09 dans la conception de protocoles pour le traitement d'infections comme celles causées par des bactéries, des champignons, des protozoaires et des virus, en particulier les infections attribuables au HIV-1 ou au HIV-2; de la douleur, du cancer; de l'anorexie; de la boulimie; de la maladie de Parkinson; de l'insuffisance cardiaque aiguë; de l'hypotension; de l'hypertension; de la rétention urinaire; de l'ostéoporose; de l'angine de poitrine; de l'infarctus du myocarde; des ulcères; de l'asthme; des allergies; de l'adénome prostatique; et des désordres psychotiques et neurologiques, y compris de l'anxiété, de la schizophrénie, de la psychose maniaco-dépressive, du délire, de la démence, de la déficience mentale sévère et de la dyskinésie, comme la maladie de Huntington ou la maladie de Gilles de la Tourette, notamment, ainsi que des épreuves diagnostiques associées.

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