A novel human map kinase homolog

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 9/12 (2006.01) C12N 15/54 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2198729

The present invention provides nucleic acid and amino acid sequences that identify and encode a novel human map kinase homolog (SMAP) expressed in cells of the human stomach. The present invention also provides for PCR oligomers or hybridization probes for the detection of nucleotide sequences encoding SMAP or SMAP-like molecules, antisense molecules to the nucleotide sequences which encode SMAP, diagnostic tests based on SMAP encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified SMAP, antibodies capable of binding specifically to SMAP, and agonists and inhibitors with specific binding activity for the polypeptide SMAP.

L'invention concerne des séquences d'acides nucléiques et d'acides aminés qui identifient et codent un nouvel homologue de la kinase humaine activée par un mitogène (SMAP), exprimée par des cellules stomacales humaines. L'invention concerne également des oligomères pour PCR ou des sondes pour hydridation permettant la détection de séquences nucléotidiques codant pour des molécules de SMAP ou analogue, des molécules antisens par rapport aux séquences nucléotidiques codant SMAP, des tests de diagnostic basés sur des molécules d'acide nucléique codant SMAP, des vecteurs d'expression obtenus par génie génétique et des cellules hôtes pour la production de SMAP purifiée, des anticorps capables de se lier spécifiquement à SMAP purifiée, des anticorps capables de se lier spécifiquement à SMAP, ainsi que des agonistes et des inhibiteurs capables de se fixer d'une manière spécifique au polypeptide SMAP.

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