A novel human mrna editing enzyme

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/52 (2006.01) A61K 38/43 (2006.01) C07K 16/40 (2006.01) C12N 9/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2260740

The present invention provides a polynucleotide which identifies and encodes a novel human mRNA editing enzyme (REE). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding REE. The invention also provides for the use of substantially purified REE and its agonists, antagonists, or inhibitors in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of REE. Additionally, the invention provides for the use of antisense molecules to REE in pharmaceutical compositions for treatment of diseases associated with the expression of REE. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding REE or anti-REE antibodies which specifically bind to REE.

La présente invention se rapporte à un polynucléotide qui identifie et code un nouvel enzyme humain d'édition de l'ARN messager (REE). L'invention se rapporte à des vecteurs d'expression issus du génie génétique et à des cellules hôtes comportant la séquence nucléotidique codant ledit enzyme REE. L'invention se rapporte également à l'utilisation de REE sensiblement purifié et de ses agonistes, antagonistes ou inhibiteurs dans des protéines produites par recombinaison à une échelle commerciale et dans des compositions pharmaceutiques en vue du traitement de maladies associées à l'expression du REE. L'invention se rapporte en outre à l'utilisation de molécules antisens du REE dans des compositions pharmaceutiques en vue du traitement de maladies associées à l'expression du REE. L'invention se rapporte enfin à des dosages diagnostiques qui utilisent ces compositions diagnostiques contenant ledit polynucléotide, ses fragments ou son complément, qui s'hybrident à la séquence génomique ou le produit de transcription des polynucléotides codant le REE ou les anticorps dirigés contre le REE qui se lient de manière spécifique au REE.

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