C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/16 (2006.01) A61K 38/22 (2006.01) A61P 43/00 (2006.01) C07K 14/575 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2332126
The present invention relates to novel human thrombopoietin (; hTPO) derivatives, and to process of preparation thereof. Particularly, sugar chains are introduced into native hTPO by substituting amino acids such as asparagine for amino acids at specific positions in native hTPO, preparing novel hTPO derivatives with high activities enhancing the platelet production in vivo. Therefore, the novel hTPO derivatives of this invention may be useful for the treatment of thrombocytopenia associated with anticancer therapy or the transplantation of bone marrow.
L'invention concerne de nouveaux dérivés de thrombopoïétine humaine (hTPO), et un procédé de préparation de ces dérivés. Ce procédé consiste à introduire des chaînes glucidiques dans la hTPO naturelle en substituant des acides aminés tels que l'asparagine à des acides aminés se trouvant dans des positions spécifiques dans la hTPO naturelle, à préparer de nouveaux dérivés de hTPO qui ont une activité importante entraînant un accroissement de la production in vivo de plaquettes. Ces nouveaux dérivés de hTPO peuvent par conséquent s'avérer utiles pour le traitement de la thrombocytopénie associée aux traitements anticancéreux ou aux greffes de moelle osseuse.
Ahn Hyea Kyung
Chang Woo Ik
Chung Joo Young
Ju Sang Myoung
Koh Yeo Wook
Daewoong Pharmaceutical Co. Ltd.
Sim & Mcburney
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