A novel member of the il-1 family, il-1 delta

Details A novel member of the il-1 family, il-1 delta A novel member of the il-1 family, il-1 delta

C - Chemistry, Metallurgy

12

N

C12N 15/25 (2006.01) A61K 31/70 (2006.01) A61K 38/20 (2006.01) A61K 48/00 (2006.01) C07K 14/545 (2006.01) C07K 16/24 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2221866

IL-1 delta polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IL-1 delta polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (e.g. inflammatory bowel disease, psoriasis), transplant rejection, graft versus host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, bone diseases (e.g. osteoporosis), cancer (e.g. lymphoproliferative disorders, atherosclerosis, and Alzheimers's disease, among others, and diagnostic assays for such conditions.

Sont décrits des polypeptides et des polynucléotides de l'IL-1 delta et des méthodes de production de ces polypeptides au moyen de techniques de recombinaison. Sont également décrites des méthodes d'utilisation des polypeptides et des polynucléotides de l'IL-1 delta dans la conception de protocoles de traitement des états pathologiques suivants : inflammation chronique et aiguë, arthrite, septicémie, maladies auto-immunes (p. ex. maladie inflammatoire de l'intestin, psoriasis), rejet de greffe, réaction du greffon contre l'hôte, infection, accident vasculaire cérébral, ischémie, syndrome de détresse respiratoire aiguë, resténose, lésions cérébrales, sida, affections des os (p. ex. ostéoporose), cancer (p. ex. affections lymphoprolifératives), athérosclérose et maladie d'Alzheimer, entre autres, et d'épreuves diagnostiques pour ces états pathologiques.

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