C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/14 (2006.01) A61K 38/17 (2006.01) C07K 7/08 (2006.01) C07K 9/00 (2006.01) C07K 14/47 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2126212
2126212 9312139 PCTABS00022 The present invention provides a novel molecule which inhibits the biological activity of neuropeptide tyrosine (NPY). The molecule of the present invention binds with an affinity of at least 100 nM to one of the helical domains of NPY in a manner such that NPY with the molecule bound thereto cannot bind to the NPY-Y1 receptor. It is preferred that the molecule of the present invention is a peptide and preferably a peptide of the sequence Ser-Ala-Leu-Arg-His-Tyr-NH2. The present invention also relates to compositions including this molecule and to the use of these compositions in treating a range of disease states.
Inglis Adam S.
Potter Erica
Selbie Lisa
Tseng Albert
Garvan Institute Of Medical Research
Prince Of Wales Medical Research Institute
Swabey Ogilvy Renault
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