C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 31/00 (2006.01) A61K 31/56 (2006.01)
Patent
CA 2269134
The invention relates to a new polymorphic crystalline form of S-fluoromethyl 6.alpha.,9.alpha.-difluoro-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-17.alpha.- propionyloxyandrosta-1,4-diene-17.beta.-carbothiate (fluticasone propionate). The new polymorphic crystalline form is easily handled and easily fluidised and its particle size and shape can be controlled. The invention also relates to the use of this new material in therapy, particularly in the treatment of respiratory disorders, e.g. asthma.
L'invention concerne une nouvelle forme cristalline polymorphe de S-fluorométhyle 6 alpha ,9 alpha -difluoro-11 beta -hydroxy-16 alpha -méthyle-3-oxo-17 alpha -propionyloxyandrosta-1,4-diène-17 beta -carbothiate (propionate de fluticasone). La nouvelle forme cristalline polymorphe permet une manipulation et une fluidisation faciles, et la taille ainsi que la forme de ses particules peuvent être controlées. L'invention concerne également l'utilisation de cette nouvelle matière en thérapeutique, en particulier, dans le traitement de troubles respiratoires comme l'asthme.
Glaxo Group Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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