A novel process for the preparation of 3-amino-pentan-1,5-diol

Details A novel process for the preparation of 3-amino-pentan-1,5-diol A novel process for the preparation of 3-amino-pentan-1,5-diol

C - Chemistry, Metallurgy

07

C

C07C 213/02 (2006.01) C07C 215/10 (2006.01) C07C 269/04 (2006.01) C07C 269/06 (2006.01) C07C 271/16 (2006.01) C07C 271/22 (2006.01)

Patent

CA 2690327

The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-1,5-diol (2), which is useful for the preparation of 6-(2,4- difluorophenoxy)-2-[3-hydroxy-1-(2- hydroxyethyl)-propylamino]-8-methyl-8H- pyrido[2,3--d]pyrimidine-7-one (1) a MAP -kinase inhibitor useful in the treatment of rheumatoid arthritis.

La présente invention concerne un nouveau procédé destiné à la préparation d'un intermédiaire clé, le 3-amino-pentan-1,5-diol (2), qui est utile pour la préparation de 6-(2,4- difluorophénoxy)-2-[3-hydroxy-1-(2-hydroxyéthyl)-propylamino]-8-méthyl-8H- pyrido[2,3-d]pyrimidine-7-one (1), un inhibiteur de la MAP kinase utile dans le traitement de la polyarthrite rhumatoïde.

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