C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 209/52 (2006.01) C07C 209/70 (2006.01) C07C 209/88 (2006.01) C07C 211/42 (2006.01)
Patent
CA 2448499
(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine (sertraline) is prepared by hydrogenating of N-[4-(3,4-dichlorophenyl)-3,4- dihydro-1(2H)-naphthalenylidene]methanamine in the presence of a dehalogenation inhibitor, e.g. triphenylphosphite or trimethylphosphite and a catalyst.
On prépare de la (1S-cis)-4-(3,4-dichlorophényl)-1,2,3,4-tétrahydro-N-méthyl-1-naphtalènamine (sertraline), en hydrogénant de la N-[4-(3,4-dichlorophényl)-3,4-dihydro-1(2H)-naphtalènylidène]méthanamine en présence d'un inhibiteur de déhalogénation, par exemple à base de triphénylphosphite ou de triméthylphosphite, et d'un catalyseur.
Fermion Oy
Orion Corporation Fermion
Robic
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