C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 257/12 (2006.01) C07D 239/94 (2006.01) C07D 405/04 (2006.01)
Patent
CA 2740977
The present invention relates to an improved and novel process for the preparation of high purity crystalline base of Lapatinib of formula-(1) having chemical name N-{3-chloro-4-[(3- fluorobenzyloxy]phenyl}-6-[5-({[2-(methanesulfonyl) ethyl]amino}methyl]-2-furyl]-4-quin - azolinamine and its pharmaceutically acceptable salts. The present invention further relates to intermediates according to formula (8) and formula (9) used in this process
La présente invention concerne un procédé nouveau et amélioré de préparation de la base sous forme cristalline et de pureté élevée du Lapatinib de formule (1) dont le nom chimique est N-{3-chloro-4-[(3-fluorobenzyloxy]phényl}-6-[5-({[2-(méthanesulfonyl)éthyl]amino}méthyl]-2-furyl]-4-quinazolinamine et de ses sels de qualité pharmaceutique. La présente invention concerne également des intermédiaires selon les formules (8) et (9) utilisés dans ce procédé.
Adibhatla Kali Satya Bhujanga Rao
Chowdary Nannapaneni Venkaiah
Jyothi Prasad Ramanadham
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Natco Pharma Limited
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