C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2170627
This invention provides a novel nucleic acid molecule encoding a prostate/colon tumor suppressor gene product. The means and methods for detecting mutations and/or loss of prostate/colon tumor suppressor gene are provided. Also included within the scope of this invention are methods of suppressing the neoplastic phenotype of cancer cells having a defect in the prostate/colon tumor suppressor gene product. The invention also includes the means and methods for treating the cancer by administering the prostate/colon tumor suppressor gene.
L'invention porte sur une nouvelle molécule d'acide nucléique codant un produit génique suppresseur des tumeurs de la prostate et du colon et sur des moyens et méthodes de détection des mutations et/ou pertes dudit gène suppresseur. Elle porte également sur des méthodes de suppression du phénotype néoplasique de cellules cancéreuses présentant un défaut dans ledit produit génique, et sur des moyens et méthodes de traitement du cancer par administration du susdit gène suppresseur de tumeurs de la prostate et du colon.
Bookstein Robert
Isaacs William B.
Canji Inc.
Gowling Lafleur Henderson Llp
The Johns Hopkins University
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