A novel proteosome-liposaccharide vaccine adjuvant

Details A novel proteosome-liposaccharide vaccine adjuvant A novel proteosome-liposaccharide vaccine adjuvant

A - Human Necessities

61

K

A61K 39/02 (2006.01) A61K 39/00 (2006.01) A61K 39/095 (2006.01) A61K 39/108 (2006.01) A61K 39/112 (2006.01) A61K 39/116 (2006.01) A61K 39/145 (2006.01) A61K 39/36 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) C07H 1/00 (2006.01) C07K 1/00 (2006.01)

Patent

CA 2438425

An adjuvant complex composed of bacterial outer membrane protein proteosomes complexed to bacterial liposaccharide is prepared to contain the component parts under a variety of conditions. The complex can be formulated with antigenic material to form immunogenic compositions, vaccines and immunotherapeutics. An induced immune response includes protective antibodies and/or type 1 cytokines is shown for a variety of protocols.

L'invention concerne un complexe d'adjuvant composé de protéosomes de protéine de membrane extérieure bactérienne complexées avec de la liposaccharide bactérienne, lequel complexe est préparé de manière à contenir les composants dans une large gamme de conditions. Le complexe peut être formulé à l'aide d'un matériau antigénique pour permettre l'élaboration de compositions immunogénétiques, de vaccins et d'immunothérapies. Une réponse immunitaire induite comprend des anticorps protecteurs et/ou des cytokines de type 1 pour une large gamme de protocoles.

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