A novel receptor trem(triggering receptor expressed on...

Details A novel receptor trem(triggering receptor expressed on... A novel receptor trem(triggering receptor expressed on...

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2715100

Novel activating receptors of the Ig super-family expressed on human myeloid cells, called TREM(s)(triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-1 and TREM-2 are disclosed. TREM-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not on lymphocytes and other cell types and is upregulated by bacterial and fungal products. Use of TREM-1 in treatment and diagnosis of various inflammatory diseases are also provided. TREM-2 is also a transmembrane glycoprotein expressed selectively on peripheral deindritic cells (DCs) but not on granulocytes or monocytes. DC stimulation via TREM-2 leads to DC maturation and resistance to apoptosis, and induces strong upregulation of CCR7 and subsequent chemotaxis toward macrophage inflammatory protein 3- .beta. TREM-2 has utility in modulating host immune responses in various immune disorders, including autoimmune diseases and allergic disorders

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