A novel splice variant of myd88 and uses thereof

Details A novel splice variant of myd88 and uses thereof A novel splice variant of myd88 and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2472927

The present invention relates to the field of infection and inflammation and more specifically to the field of pathogen-induced nuclear factor kappa B activation. More specifically, a novel splice variant of MyD88, (MyD88s), has been identified encoding a protein that inhibits LPS-induced NF-kappaB activation. MyD88s is a target to inhibit the phenomenon of endotoxin- tolerance that occurs in sepsis.

La présente invention concerne le domaine de l'infection et de l'inflammation, et plus particulièrement le domaine de l'activation du facteur nucléaire kappa-B induit par des pathogènes. L'invention concerne plus particulièrement l'identification d'un nouveau variant à épissage du MyD88 (MyD88s) qui code une protéine inhibant l'activation du facteur nucléaire kappa-B induit par les lipopolysaccharides. Le MyD88 est une cible permettant d'inhiber le phénomène de tolérance aux endotoxines survenant en cas de sepsie.

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