A novel therapy for treating sepsis using a soluble form of...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/725 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2133758

2133758 9319772 PCTABS00027 A method is provided for the treatment of symptoms of sepsis that are mediated by proteins that are substantially homologous to CD14 myelomonocytic antigen. A soluble form of CD14 ("sCD14") is produced by using molecular genetic techniques to express a nucleic acid sequence that encodes CD14. The soluble form of the CD14 thus produced is isolated and purified. The purified soluble CD14 is administered to mammals in order to prevent or treat the symptoms of sepsis.

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