C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A61K 31/7088 (2006.01) A61K 35/14 (2006.01) A61K 38/08 (2006.01) A61K 38/44 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C07K 16/40 (2006.01) C12N 9/02 (2006.01) G01N 33/574 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2441225
The present invention relates to a new and potent tumor antigen capable of causing T cells to elicit an immune response and methods of its use in the detection, prevention, and treatment of cancer, preferably melanoma, in mammals. More specifically, this invention relates to the identification of a novel tyrosinase-related protein 2 (TRP2), specifically TRP2-6b protein, and peptides derived from said protein. The present invention therefore also relates to nucleic acid sequences that encode the TRP2-6b protein or peptide fragments thereof.
L'invention porte sur un nouvel antigène puissant capable d'amener les cellules T à générer une réponse immunitaire, et sur ses méthodes d'utilisation pour la détection, la prévention, et le traitement du cancer, de préférence du mélanome du mammifère. L'invention porte plus particulièrement sur l'identification d'une nouvelle protéine parente de la tyrosinase, la 2 (TRP2), plus précisément la protéine TRP2-6b, et sur des peptides en dérivant. L'invention porte en outre sur des séquences d'acides nucléiques codant pour la protéine TRP2-6b ou ses fragments peptidiques.
Khong Hung
Rosenberg Steven A.
Department Of Health And Human Services The Government Of The United States Of America As Represented By
Ridout & Maybee Llp
LandOfFree
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